Signal Transduction in Health and Disease

Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

At the end of this theoretical course, the students are aware of the
latest insights of cellular signal transduction in both healthy and
pathological conditions.

Inhoud vak

This course will link human genetic variations (somatic and inherited
mutations) to the development of disease and will focus on pathological
signaling, mutant signaling proteins in disease and possible treatment
of resulting disease (small compounds, biologicals, gene therapy).
Modern pharmacological concepts, including constitutive receptor
activity, receptor regulation, allosteric modulation and dimerization
will be addressed in light of signal transduction in health and disease.
A special focus will be on signal transduction resulting in pathologies
such as Alzheimer, Parkinson’s disease, inflammatory diseases and


Lectures, self-study, assignment(s)
Students will do a case study in groups focusing on a recent primary
research article, which focuses on a signaling pathway
linked to disease. Molecular mechanisms underlying the pathology need to
addressed and presented. Therapeutic targeting of this signaling
pathway will be addressed and discussed.


Assignment and presentation, written exam.


'Cell signaling', Authors: Wendell Lim, Bruce Mayer, Tony Pawson
ISBN: 9780815342441
Format: Paperback
Publication Date: June 15, 2014

Research articles and additional theoretical background will be
available on Canvas


var, mDDS-E-var, mDDS-M-var, mMNS-MCD, mMNS-MPy

Aanbevolen voorkennis

Bachelor Biology, Medical Biology, Pharmaceutical Sciences, Medical
Natural Sciences, Biomolecular Science portal course or equivalent

Algemene informatie

Vakcode X_432535
Studiepunten 6 EC
Periode P2
Vakniveau 500
Onderwijstaal Engels
Faculteit Faculteit der Bètawetenschappen
Vakcoördinator prof. dr. M.J. Smit
Examinator prof. dr. M.J. Smit
Docenten prof. dr. M.J. Smit
dr. ir. A.H. de Boer
dr. M.H. Siderius

Praktische informatie

Voor dit vak moet je zelf intekenen.

Voor dit vak kun je last-minute intekenen.

Werkvormen Hoorcollege

Dit vak is ook toegankelijk als: