Advanced Clinical Neurosciences

Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

The overall aim of the Advanced Clinical Neuroscience course is to learn
how to design, perform and critically evaluate clinical neuroscience.
Specific learning goals are as follows:
1. The student is able to design clinical neuroscientific research
1.1 The student is able to list the most important clinical features of
the five brain disorders that are central to this course (Alzheimer’s
disease, Parkinson’s disease, multiple sclerosis, neuro-oncology,
obsessive compulsive disorder)
1.2 The student is able to identify relevant diagnostic problems within
these disorders
1.3 The student is able to construct hypotheses directed at solving
these diagnostic problems
1.4 The student can design a research study about a clinical
neuroscientific topic
2. The student can perform clinical neuroscientific research
2.1 The student can recite techniques and methods used within
2.2 The student is able to apply and administer these methods within the
five main diseases
2.3 The student can choose the correct statistics to test his/her
3. The student is able to critically evaluate clinical neuroscientific
3.1 The student is able to formulate pros and cons of a clinical
scientific grant proposal
3.2 The student is able to apply their knowledge to criticize the
scientific quality of clinical neuroscientific papers

Inhoud vak

This course will involve lectures, workshops, and a clinical internship
to familiarize students further with clinical neuroscience. They are
expected to design and present a neuroscientific study of their own
interest. They will integrate the current scientific state of the art
with clinical patient presentation in a written case report. They will
also gain experience in the process of peer review.


Lectures (10 contact hours)
For each of the five main disorders, a clinical lecture will focus on a
stringent/current problem that needs solving. We assume basic knowledge
on each disorder, so that we can discuss the problem in depth. These
lectures will mostly be taught by the coordinators, or an expert in the
field. This clinical lecture is paired with a research lecture, in which
an (innovative) approach towards solving a (perhaps not the same)
problem. These lectures will be given by researchers in the field. The
students are expected to prepare a single paper for each lecture and may
be quizzed on their preparation during the lecture.

Clinical internship (4-8 contact hours)
For further familiarization with the clinical aspects of neuroscience,
students will be able to do an internship in the outpatient clinic at
the VUmc. They will shadow an MD, attend research meetings and/or
multidisciplinary clinical meetings. For non-Dutch speaking students,
these meetings will be in English. Furthermore, students have the
opportunity to do an internship with a clinical neuroscientist.

Clinical neuroscience methods workshops (8 contact hours)
In order to further provide students with the tools necessary to conduct
clinical neuroscience, a series of hands-on workshops will be taught
(mostly by coordinators, in addition to experts). Topics include brain
stimulation, animal studies, neuropsychological testing, scientific
writing and presenting, epidemiology and trial design, peer-review and
others. Participation during these workshops is essential.


• Scientific abstract presentation (30% of final grade)
• Peer review team assignment (team grade, counts towards 20% of
individual final grade)
• Written case report (30%)
• 5 pop quizzes (20%), of which 1 grade can be dropped from the final
• No other compensation between these assessments is possible

Vereiste voorkennis

Principles of Neuroscience (470701), Clinical Neuroscience (470757)


A number of recent relevant reviews, peer-reviewed articles and chapters
will be posted on Canvas.


Msc Neuroscience students, 2nd year following Track Clinical
Other Msc Neuroscience students with interest in Clinical Neurosciences.

Overige informatie

There is a maximum of 25 students. For further information and
application, please contact the course coordinators: dr. L. Douw or dr.
Hanneke Hulst (

Afwijkende intekenprocedure

Registration via VUnet, please inform us ( if you switch after signing up through VUnet!

Algemene informatie

Vakcode AM_1014
Studiepunten 6 EC
Periode P1
Vakniveau 600
Onderwijstaal Engels
Faculteit Faculteit der Bètawetenschappen
Vakcoördinator dr. L. Douw
Examinator H.E. Hulst
Docenten dr. L. Douw

Praktische informatie

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Werkvormen Werkcollege, Hoorcollege, Werkgroep