Methods in behavioral neurosciences

2018-2019
Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

The course will give an overview of methods, the behavior tests and its
measures (used in a number of different research areas in behavioral
neuroscience), and the interpretation of these data. By means of expert
knowledge from those who are actively involved in the newest techniques
and topics, we will provide you with a critical overview of how you are
able to integrate behavioral phenotyping with molecular and cellular
studies to find causal relations in biomedical research using models for
human disorders/diseases. The course aims to develop critical thinking
in behavioral research.

Inhoud vak

In behavioral and molecular neuroscience we study how different brain
areas are involved in the control and execution of behavior.
Importantly, the methods used have to capture important aspects of the
normal behavior of the animal, and the interference used for studying
causal aspects of cells/molecules in that behavior should not confound
this type of normal behavior. In order to obtain results that are both
reproducible and reliable it is important to that the methods used are
standardized and that there is agreement on what the measures actually
mean (its interpretation).

The following topics will be covered to better understand and judge the
behavior test spectrum and its use in behavioral phenotyping:
- Standardized tests of learning and memory
- Home cage-based phenotyping
- Attention and impulsivity
- Anhedonic and cognitive aspects of depression models
- Autonomic functions in behavior as index of emotion
- Animal welfare under dutch law

In addition, for evaluation of the molecular and cellular mechanisms
that drive these behaviors the following topics are covered
- Animal models for tagging neuronal activity
- Optogenetics and chemogenetics in behavioral neuroscience

Onderwijsvorm

Lectures and discussion based on primary research papers / unpublished
data will be mainly in week 1. Demonstrations will be given when
compatible with the current experiments. Individual or pairs will
interact on a 1-to -1 basis with a supervisor of choice in preparation
of
a mini-literature review (mainly week 2-4).

Toetsvorm

1) Student presentation on mini-review (21%)
2) Written mini-review for the jointly prepared manuscript (49%)
3) Written examination with open-ended questions (30%)
In all three assessment forms the minimal grade has to be 5.5 to pass
the course.

Vereiste voorkennis

Basic knowledge of animal behavior.

Literatuur

Primary literature (papers) generally provided through digital Canvas.

Doelgroep

MSc Biology and MSc Neurosciences students

Overige informatie

There is a minimum of 6 participants in the course, and a maximum of 15
participants. Mind to mail to the coordinator in case you did subscribe,
but you are not going to follow the course.

Afwijkende intekenprocedure

There is a minimum of 6 participants in the course, and a maximum of 15 participants. Mind to mail to the coordinator in case you did subscribe, but you are not going to follow the course.

Algemene informatie

Vakcode AM_470728
Studiepunten 6 EC
Periode P2
Vakniveau 500
Onderwijstaal Engels
Faculteit Faculteit der Bètawetenschappen
Vakcoördinator prof. dr. S. Spijker
Examinator prof. dr. S. Spijker
Docenten prof. dr. S. Spijker

Praktische informatie

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