Statistics for High-Dimensional Data

2018-2019
Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

Teaching students the adjustments to classical statistical methodology,
necessary to tackle high-dimensional data.

Inhoud vak

This course gives an overview of statistical methods that are used for
analyzing high-dimensional data sets in which many variables (often
thousands) have been measured for a limited number of subjects. This
type of data arises in genomics, where genetic information is measured
for many thousands of genes simultaneously, in functional MRI imaging of
the brain, and also in economic applications. The course covers some of
the most important statistical issues for high-dimensional data,
including: a) initial processing of the data; b) model-based
statistical inference for Gaussian and count data (classical and
Bayesian methods); c) multiple testing (family-wise error rate and false
discovery rate control); d) prediction of binary endpoints (e.g.
recurrence of a tumor) and survival; e) clustering of samples (e.g. to
find tumor subtypes). Several specific types of high-dimensional data
will be discussed and used during the course. In terms of applications
the course focuses on cancer genomics, but theoretical aspects will
apply to other fields as well.

Onderwijsvorm

Lectures + practical exercises

Toetsvorm

Written exam

Literatuur

Tutorial in biostatistics: multiple hypothesis testing in genomics" by
Goeman & Solari (article in Statistics in Medicine) plus handouts
provided by the lecturer

Doelgroep

mMath, mSFM

Afwijkende intekenprocedure

This course is offered every other year. The next opportunity to enroll will be 2019-2020.

Aanbevolen voorkennis

Algemene statistitiek, Statistical Data Analysis

Algemene informatie

Vakcode X_405113
Studiepunten 6 EC
Periode P4+5
Vakniveau 400
Onderwijstaal Engels
Faculteit Faculteit der Bètawetenschappen
Vakcoördinator dr. M. van de Wiel
Examinator dr. M. van de Wiel
Docenten

Praktische informatie

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Werkvormen Hoorcollege
Doelgroepen

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