Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.
Doel vakTo gain insight into
- the theoretical principles underlying human genetics
- the current state of the art of genome-wide discovery studies
- the current state of the art in gene finding for brain related traits
- the methods currently used to analyse large genetic datasets
- the current state of the art in tools that can be applied to gain
biological insight into genetic findings
- how to critically evaluate results from genetic discovery studies
- how genetics and neurobiology can inform each other
Inhoud vakThe course is offered to students in the Master of Neurosciences.
The main goal is to teach how genetic discovery studies are conducted,
how results of such studies should be interpreted and how they can be
used to conduct neurobiological studies. The lectures will provide a
comprehensive overview of the current revolution in the field of human
genetics, and will also lay-out the theoretical foundations of the
field. In addition, the lectures aim to provide starting points for
bridging human genetics and neurobiology.
Parts of the lectures and practicals are of statistical nature, yet all
will be accompanied by examples of how to apply statistical methods to
gaining insight into the genetics of brain-related traits. Practical
sessions are aimed at providing hands-on experience with current
analytical tools and fostering a critical opinion on published studies
in this field.
Onderwijsvorm7 lectures (3 hours) and 11 practicals and workgroups (3 hours)
Contact hours: 54 hours distributed over 12 days
Lecture material: powerpoints + scientific papers.
Assignments (to be made during the
practicals, and returned via e-mail. They are not scored but need to be
complete). Assignments consists of
- practical exercises using R
- practical exercises using shell scripting
- practical exercises using genetic tools (e.g. Plink, FUMA, MAGMA,
- critical reading and discussion of scientific papers (workgroup
ToetsvormTwo written exams in two parts: in week 5 and in week 8.
Two group presentations: in week 4 and week 8
The final score is the weighted average of .4*exam1 + .4*exam2 +
.1*presentation1 + .1* presentation2
Parts can not compensate, all components have to be awarded a sufficient
grade (5.5. or higher) in order to receive a sufficient final grade.
Grading: 1) practical attendance is a necessary condition to pass this
Practicals are mandatory
Offered for the two written exams. Part 1 and 2 are offered in a single
Students can miss a maximum of 1 practical (with valid reason). A missed
practical has to be compensated.
DoelgroepStudents in the Master of Neurosciences
|Faculteit||Faculteit der Bètawetenschappen|
|Vakcoördinator||prof. dr. D. Posthuma|
|Examinator||prof. dr. D. Posthuma|
Voor dit vak moet je zelf intekenen.
Voor dit vak kun je last-minute intekenen.
|Werkvormen||Deeltoets extra zaalcapaciteit, Hoorcollege, Computerpracticum|