Hot Topics in Psychiatry

2018-2019
Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

As mentioned above, the course aims to provide insight into the latest
developments in psychiatric research, as well as introducing students to
novel research methods. In addition, the module teaches students to
analyze and evaluate research papers, write an opinion article and
provides opportunities to discuss ethical dilemmas within the field of
psychiatry. Collectively, these courses will serve as excellent
preparation for the Bachelor’s thesis and the scientific internship (M1
or M3).

Inhoud vak

Globally, millions of people suffer from debilitating psychiatric
disorders. At present, these disorders are incurable, which necessitates
the development of advanced prevention strategies, diagnostic tools, and
treatments. In this module, students will be exposed to the latest
developments in psychiatric research, as well to as a variety of novel
research methods (ranging from genome-wide association studies to
neuroimaging in patients). The topics covered are child and adolescent
psychiatry, forensic psychiatry, schizophrenia, autism, depression, and
comorbid somatic and neurological conditions.


Course objectives
As mentioned above, the course aims to provide insight into the latest
developments in psychiatric research, as well as introducing students to
novel research methods. In addition, the module teaches students to
analyze and evaluate research papers, write an opinion article and
provides opportunities to discuss ethical dilemmas within the field of
psychiatry. Collectively, these courses will serve as excellent
preparation for the Bachelor’s thesis and the scientific internship (M1
or M3).

The minor track consists of 3 courses:
Course 1. Crisis and forensic psychiatry
Course 2. Psychiatric genetics
Course 3: Breaking bad, or getting better?


Course 1: Crisis and forensic psychiatry

Course 1. Content
This course begins from a childhood and adolescent perspective, with
links to adult psychiatry. During this course, students are exposed to
the state-of-the-art developments in one of the most complex fields of
psychiatry: crisis and forensic psychiatry in childhood and adolescence.
What if, despite all previous efforts to help them, your patient becomes
increasingly ill, is severely traumatized, or becomes suicidal? When
problems become so severe that a patient gets into serious trouble? Or
when he or she commits a criminal act? What risk factors are involved?
And how can we improve treatment for this most vulnerable group of
patients?
The course is taught from a neurodevelopmental perspective. In week 1,
we introduce the relationship between serious somatic illness and
psychiatry (and vice versa) and consultative psychiatry. In week 2, the
suicidal patient is the central focus, including severe auto-mutilation
and autointoxication. In week 3, we focus on the threatened child,
growing up in an aggressive and unsafe environment. In week 4, we
describe the “delinquent,” the patient with severe behavioral problems
such as aggression, impulsivity and drug abuse, with a focus on the role
of psychiatric problems in the development of (persistent) delinquent
behavior.
Each week and topic begins with a patient or clinical case, from which
starting point questions are developed, such as: What neurodevelopmental
mechanisms have led to this kind of complex problems? What
environmental, psychological and neurobiological mechanisms are
involved? What do we know from research about this type of patient? What
further research is needed, and how could that be designed? What
(evidence-based) treatments are available? Each week will consist of
interactive lectures, work groups and an excursion (e.g., to a closed
psychiatric ward, closed youth care institution, juvenile justice
institution).

Course 1. Learning objectives
Upon successful completion of this course, students should be able to:
1. describe and explain complex psychiatric problems in crisis and
forensic psychiatry
2. describe and interpret (neurodevelopmental) risk factors for
psychiatric problems in crisis and forensic psychiatry
3. summarize, critically analyse, and reflect on research papers in the
field of crisis and forensic psychiatry
Course 1. Type of assessment
Short written assignments (mid-term) and written exam consisting of
open-ended questions (final exam)

Course 2: Psychiatric genetics

Course 2. Content
This course provides a comprehensive overview of the current state of
the art in the field of psychiatric genetics. It covers basic concepts
such as heritability and the difference between Mendelian and
(genetically) complex disorders. Recent results from genome-wide
association and sequencing studies within psychiatric genetics are
covered in depth. Finally, we will discuss the importance of
cutting-edge techniques like pluripotent stem cell cultures (iPSC) in
the understanding of complex psychiatric disorders.

Course 2. Learning objectives
Upon successful completion of this course, student should be able to:
(1) explain the concept of (missing) heritability and interpret
heritability estimates of psychiatric disorders
(2) explain the difference between Mendelian and (genetically) complex
disorders and its implication for psychiatric genetics
(3) describe and interpret genome-wide association studies and (exome)
sequencing studies
(4) describe gene-set analysis and explain its rationale
(5) explain the importance of iPSC studies for psychiatric genetics
(6) summarize, critically analyze, and reflect on research papers in the
field of psychiatric genetics
(7) pitch a research proposal in the field of psychiatric genetics
Course 2. Type of assessment
Open-ended and closed question exams and oral presentation (in groups).

Course 3: Breaking bad, or getting better?

Course 3. Content
“Malfunctioning” in everyday life may be due to a psychiatric disorder,
with the most common disorders being anxiety and mood disorders.
Considerable overlap exists between psychiatric, somatic and
neurological conditions and, therefore, treatment may take many
different forms. Depending upon the level of patient cooperativeness and
commitment, psychotherapy, pharmacotherapy, somatic or neurobiological
treatments may be offered to relieve symptoms. During this course, we
examine the complex interactions between neuroscience and psychiatric
disorders in adulthood and the challenges presented in choosing a
treatment. In week 1, we focus on diagnostics in psychiatric disorders.
Current genetic and imaging research is presented and discussed, with
particular attention to risk factors for psychiatric disorders. In week
2, we discuss somatic comorbidities in psychiatric patients, focussing
upon prevention. Examples include cardiovascular and neuroendocrine
comorbidities, drug and alcohol dependency, and psychiatric comorbidity.
The focus of discussion is on ethical implications of treatment choice.
In week 3, we discuss motivational techniques. Practical skills are
taught under the guidance of experienced psychologists. Use of E-health
treatment, apps, and internet, are also practiced. Novel treatment
options are discussed, such as transcranial magnetic stimulation, deep
brain stimulation, and neuro-immunological treatments. In week 4,
evaluation of currently available treatment is the central theme.
Results of relevant meta-analyses are presented, and their implications
for the individual patient discussed. Currently available
(evidence-based) treatment is presented, leading to a discussion
focusing on neuroscientific research aimed at improving patient outcome.
Course 3. Learning objectives
Upon successful completion of this course, students should be able to:
1. explain the role of epidemiology in attaining a better understanding
of common mental disorders
2. describe and interpret factors that determine the course and
treatment outcomes of common mental disorders
3. describe current research developments in the field of psychiatry,
and reflect on their use and shortcomings in everyday clinical practice
4. outline and discuss the use of Big Data in mental health research
5. design an effective research recruitment poster

Course 3. Type of assessment
Written assignment, debate participation, written exam

Onderwijsvorm

Lectures, discussions, study groups, practicals, patient-presentations,
excursions

Toetsvorm

Written assignments, debate, written exams, oral presentation.

Literatuur

An overview of the study material is placed on CANVAS.

Doelgroep

Third year Bachelor’s students in Medicine, with an active interest in
psychiatry. Also eligible are third year Bachelor’s students from
related life sciences disciplines, possessing the required level of
background knowledge (i.e. pathological mechanisms and symptoms of
common psychiatric disorders).

Overige informatie

Research theme: Neurosciences
Research institutes: Amsterdam Neuroscience, EMGO
Departments: Department of Anatomy & Neurosciences, Child- and
adolescent psychiatry, GGZinGeest, Psychiatry, and Complex trait
genetics (Fac. of Science)
Track coordinator: Leontien Diergaarde, PhD
Course coordinators: Lucres Nauta, PhD; Danielle Posthuma, PhD; Sven
Stringer, PhD; Adrie Seldenrijk, PhD

Afwijkende intekenprocedure

Before the start of the semester, students will be invited to select their preferred minor track. However, the Institute of Education and Training (IET) will make a final selection based on both student preferences and availability in the different tracks. Once you have been selected for a track, the IET will make sure you’re registered for all educational activities such as study groups, courses, and exams. Important: Please be aware that in the case that you do not pass an exam, you will NOT be automatically registered for a re-examination, and will need to do this yourself. In order to sign up to resit an examination, you will need to apply no later than 2 weeks before the re-examination through the form “Re-take Exam Bachelor of Medicine.”

Toelichting Canvas

This course is supported by a corresponding CANVAS course, which
contains all of the required information of this course including
overview of the required articles and assignments. The CANVAS course
will also be used to post announcements relevant to the course. You will
automatically have access to the CANVAS course.

Aanbevolen voorkennis

Level 200 knowledge of pathological mechanisms and symptoms of common
psychiatric disorders.

Algemene informatie

Vakcode M_BHTP16
Studiepunten 18 EC
Periode Semester 1
Vakniveau 300
Onderwijstaal Engels
Faculteit VUmc
Vakcoördinator dr. L. Diergaarde
Examinator dr. L. Diergaarde
Docenten dr. A.S. Seldenrijk

Praktische informatie

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Werkvormen Hoorcollege, Studiegroep, Practicum