Introduction to Systems Biology

2019-2020
Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

Introduction to Systems Biology is the starting course of the
Bioinformatics and Systems Biology master (together with Fundamentals of
Bioinformatics).

Goals:
- To make the student acquainted with the major approaches and
methodology in systems biology (to be studied in more detail in the
master).
- To develop a basic understanding of biological concepts that are
relevant to current topics in systems biology.
- To gain hands-on experience in basic modelling as a means of solving
systems biology problems.
- To repair gaps in background knowledge.

Inhoud vak

Theoretical topics:
- The two branches of systems biology
- Data structure, geometrical mapping, PCA, distance metrics, clustering
- Cellular composition, diffusion, time scales, rates
- Mass-action, mass balances, reactions, equilibria, stable/unstable
steady states equilibrium binding, affinity, conformational change,
ultrasensitivity, transduction cascades, autoregulation, mutual
inhibition/activation, bistability, feed-forward loops, steady state
metabolism, regulation of metabolism and regulation by demand

Practical:
- Exercises during/in between lectures in which methods of systems
biology will be applied to several topics.

- Conversion classes
Depending on their background, students will also be assigned to two out
of three deficiency classes where they will be working to fill gaps in
their knowledge in mathematics, programming and/or biology.

Onderwijsvorm

- Lectures (two hour lecture in the morning, two days per week)
- Computer- and modelling practicals
- Conversion classes in biology, mathematics and/or programming

Doelgroep

Students with a bachelor degree in Biology, Bioinformatics, Mathematics,
Physics or similar background

Aanbevolen voorkennis

Mathematics at highschool level

Algemene informatie

Vakcode X_428565
Studiepunten 6 EC
Periode P1
Vakniveau 400
Onderwijstaal Engels
Faculteit Faculteit der Bètawetenschappen
Vakcoördinator dr. D. Molenaar
Examinator dr. D. Molenaar
Docenten dr. D. Molenaar
prof. dr. B. Teusink
prof. dr. F.J. Bruggeman

Praktische informatie

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